ACHE and early-onset autosomal dominant Alzheimer disease: The domain-specific improvement in short-term memory was very different from the therapeutic response expected in Alzheimer disease, where benefits from acetylcholinesterase inhibitors mainly result in attention, executive, language, and visuospatial function.[10,11] From a neuroradiological viewpoint, the symmetric hypoperfusion within the frontal–temporal regions on SPECT represents a distinct pattern from Alzheimer disease-related pathology.