In addition to BaP-mediated mutagenesis and carcinogenesis through DNA adduct formation, there are also reports of apoptosis induced by BaP metabolites in different human cell lines: Daudi B cells [52], H460 lung cancer cells [53], hepatoma HepG2 cells [54] and endometrial cancer RL95-2 cells [55], the latter two being directly associated with CYP-mediated metabolism of BaP. The gene discussed is PPIG; the disease is lung carcinoma.