Performing studies on animal models of neurodegenerative diseases is a widely used approach to advance the understanding of pathogenic mechanisms, but there have been varying results about the association of iron with plaques in mouse models of AD, in particular, the widely used APP/PS1 double transgenic mouse (Falangola et al., 2005; Jack et al., 2005; El Tannir El Tayara et al., 2006; Meadowcroft et al., 2009; Dong et al., 2015; Guo et al., 2015; Meadowcroft et al., 2015). This evidence concerns the gene APP and Alzheimer disease.