CD8A and T-cell non-Hodgkin lymphoma: In the CD2cre snf5fl/fl mouse, T-cell development was blocked at the DN3 stage and no lymphoma developed, but introduction of the OT1 TCR transgene into the CD2cre snf5fl/fl mouse resulted in the presence of mature T cells in the periphery and all mice developed CD3+CD8+ T-cell lymphomas.