Expression of Itk-Syk via CD4 promoter-driven Cre in transgenic mice leads to peripheral CD4 and/or CD8 SP T-cell lymphoma in mice with tumour cells having an activated T-cell phenotype (CD62loCD44hi; also indicative of an effector memory T cell) [29]. The gene discussed is CD8A; the disease is T-cell non-Hodgkin lymphoma.