FMR1 and neoplasm: Furthermore, higher FMRP+ IOD was associated with bigger tumor size (P<0.05, ≤30 cm3 vs. >30 cm3), higher grade tumors (P<0.05, grade II vs. grade III/IV), and higher expression Ki67 (P<0.05, ≤5% vs. >5%), but not with sex or age (Table 1).