15 genes were present in both subsets and included in the HNSCC DNA repair gene candidate list (XRCC1, MLH3, PMS1, RAD51B, XRCC3, RAD54B, BRCA1, SHFM1, GEN1, FANCE, FAAP20, SPRTN, SETMAR, HUS1, and PER1). Here, MLH3 is linked to head and neck squamous cell carcinoma.