15 genes were present in both subsets and included in the HNSCC DNA repair gene candidate list (XRCC1, MLH3, PMS1, RAD51B, XRCC3, RAD54B, BRCA1, SHFM1, GEN1, FANCE, FAAP20, SPRTN, SETMAR, HUS1, and PER1). The gene discussed is FANCE; the disease is head and neck squamous cell carcinoma.