Most genes from the HNSCC list showed positive correlations with CTLA4 and CD274 expression in cervical and lung squamous cell carcinoma datasets with the homologous recombination genes XRCC3, RAD51B, RAD54B, SHFM1, and BRCA1, mismatch excision repair genes MLH3 and PMS1, fanconi anemia gene FAAP20 and a gene involved in ubiquitination and modification, SPRTN, exhibiting positive correlations in all tested associations (Figure 2). The gene discussed is XRCC3; the disease is head and neck squamous cell carcinoma.