Uniform hyper- or hypomethylation was mostly present in genes that showed little or no correlation in the cross-validation (e.g. OGG1 in HNSCC and LSCC, CHEK1 in HNSCC and cervical carcinoma, HUS1 in LSCC and cervical carcinoma, Figure 4). The gene discussed is HUS1; the disease is head and neck squamous cell carcinoma.