To further elucidate whether miR-135a promotes OXA resistance in GC cells by suppressing E2F1 and the DAPK2 signaling pathway, we transfected SGC7901/OXA and MGC803/OXA cells with E2F1 siRNA and pCDNA3.1-DAPK2. The gene discussed is E2F1; the disease is gastric cancer.