PDE4D and posterior cortical atrophy: The results of three different platforms determining DNA methylation patterns consistently detected hyper-methylated regions, indicating active silencing of several PDE4D promoters in PCa, involving the transcription start site (TSS) of a total of five PDE4D isoforms, namely the short PDE4D1/2 isoforms and the long PDE4D4, PDE4D5 and PDE4D8 isoforms (see Supplementary Figure S9).