The AUC for ApoA-1 was 0.60 (95% CI, 0.53–0.63; Sensitivity, 0.468; Specificity, 0.630; Youden's index, 0.098) for TTR, and 0.57 (95% CI, 0.49–0.66; Sensitivity, 0.475; Specificity, 0.673; Youden's index, 0.148) for OS, which was the strongest factor among indices (tumor number, tumor size, tumor encapsulation, tumor differentiation, vascular invasion, AFP, and BCLC stage) for predicting recurrence and survival in patients with HCC. This evidence concerns the gene APOA1 and hepatocellular carcinoma.