In this study, we described four main findings: (1) geraniol specifically induces the changes in cell cycle gene signatures; (2) geraniol reduces the expression levels of the transcription factor E2F8; (3) E2F8 controls G2/M cell cycle progression; and (4) E2F8 is up‐regulated in metastatic prostate cancer and associated with worse survival in prostate cancer patients. This evidence concerns the gene E2F8 and Familial prostate cancer.