CD4 and infection: Instead, RV infected Tbet-/- mice had increases in lung CD3+CD4+ T cells expressing both GATA binding protein 3 (GATA-3) (Fig 1B), the Th2 associated transcription factor, and RAR-related orphan receptor gamma t (RORγt) (Fig 1C), the Th17 associated transcription factor, compared to both RV infected w/t and PBS challenged Tbet-/- mice on day 7 post-infection.