CDH2 and carcinoma: Although the mechanisms regulating the aberrant expression of N-cadherin in carcinoma progression remain unknown, the Twist-1 expression has been indicated to be necessary for N-cadherin expression during gastrulation in Drosophila. Yang and colleagues suggested that Twist expression was sufficient to induce in vitro EMT [27], and Alexander and colleagues demonstrated that integrin-mediated adhesion is involved in the Twist-1 nuclear translocation and is necessary for N-cadherin expression in PC-3 prostate carcinoma cells [17].