CDH2 and gastric cancer: Twist-1, Zeb-1, and Snail are zinc-finger transcriptional repressors that bind directly to the E-boxes of the promoter of the E-cadherin coding gene, and Twist-1 has been suggested as the major regulator of N-cadherin expression during gastrulation in Drosophila and promoting the N-cadherin expression in gastric cancers [27].