To assess whether the C-terminal region contributes to the anti-tumor activity of CgA we analyzed: a) the effect of antibodies against the region 410-439 on the anti-tumor activity of exogenous recombinant CgA, b) the anti-tumor activity of CgA1-409 and CgA1-373 (i.e. fragments lacking the C-terminal region), and c) the anti-tumor activity of CgA410-439 (a fragment corresponding to the C-terminal region). This evidence concerns the gene CGA and neoplasm.