As vascularized tumors are exposed to CgA released in circulation by the neuroendocrine system, we decided to perform the study using various murine models of non-neuroendocrine solid tumors, including subcutaneous fibrosarcomas, Lewis lung carcinoma and mammary adenocarcinomas, as well as orthotopic subcutaneous and metastatic (lung) melanomas. Here, CGA is linked to melanoma.