The effect of exogenous recombinant and natural CgA (produced in E.coli cells and purified from pheochromocytomas, respectively) on tumor growth was investigated in different murine models, including WEHI-164 fibrosarcoma, TSA adenocarcinoma B16-F1 melanoma, and Lewis lung carcinoma (LLC), implanted subcutaneously in syngeneic mice. This evidence concerns the gene CGA and neoplasm.