SERPINE2 and prostate adenocarcinoma: Remarkably, recent studies have shown that PN-1 inhibits endothelial cell migration, capillary tube formation and angiogenesis in various in vitro and in vivo assays, independently of its serpin activity [36], and that overexpression of PN-1 inhibits angiogenesis and prostate adenocarcinomas growth in mice [37].