TP53 and myelodysplastic syndrome: Moreover, meta-analysis of a published cohort of MDS patients suggested that TP53 mutations are less common in patients with a complex karyotype without −7/del(7q) (6 out of 34 cases) than in those with a complex karyotype including −7/del(7q) (5 out of 9 cases; (Supplemental Table 2).