EGFR and cancer: Various cellular targets and pathways have been proposed as to the mechanism of UA's anti-metastasis effects, including: integrin-mediated focal adhesion pathway [18], extracellular signal-regulated kinase (ERK) pathway [19], epidermal growth factor receptor (EGFR) [16] and MMPs [20] pathways, and suppressing several key molecules associated with cancer metastasis [21].