Therefore, the US Food and Drug Administration approved them for treatment of patients with unresectable or metastatic melanoma and disease progression following Ipilimumab (anti-CTL4 antibody), and for B-Raf proto-oncogene, serine/threonine kinase (BRAF) V600 mutation-positive patients with a BRAF inhibitor respectively. Here, BRAF is linked to metastatic melanoma.