Because several afflictions, including cancer, arthritis, chronic inflammation, asthma, neurodegenerative diseases and heart disease have been found to be caused by misregulation of active NF-κB, countermeasures to aberrant gene expression, using artificially designed therapeutic DNA decoys have been developed with the aim of inhibiting transcription of NF-κB [14,15]. Here, NFKB1 is linked to Arthritis.