Previous reports have shown that TNF-α, IFN-γ, IL-6, IL-17, IL-23, and some monocytes are detrimental in the pathologic process of stroke [42–46], whereas Treg cells, IL-4, IL-10, and TGF-β are major cerebroprotective modulators of post-ischemic inflammatory brain damage [47–49]. This evidence concerns the gene IL4 and stroke disorder.