We analyzed the input and pellet for viral RNA and determined that immunoprecipitation of FLAG-ERI3 significantly enriched DENV-2 genomic RNA (gRNA, 21.9-fold enrichment, P = 0.02) compared to the IgG control (Fig. 2B), demonstrating that ERI3 interacts with DENV-2 RNA during infection. Here, ERI3 is linked to infection.