On the other hand, the fact that Ffar2 (GPR43)-deficient (Ffar2-KO) mice are completely protected from high-fat diet-induced obesity, dyslipidemia, and fatty liver [92] supports the importance of SCFAs/GPR43 signaling in the development of NAFLD. The gene discussed is FFAR2; the disease is metabolic dysfunction-associated steatotic liver disease.