NR1H4 and metabolic syndrome: In addition to other studies supporting the beneficial effect of FXR ligands on liver inflammation and fibrosis [100,101,102,104], the fact that FXR-deficient mice fed a methionine/choline-deficient diet (MCDD) developed more severe liver injury but a lower degree of steatosis suggests the role of BAs and FXR in maintaining liver homeostasis against metabolic syndrome.