Current European guidelines for prescribing anti-EGFR monoclonal antibody therapy (http://www.ema.europa.eu/docs/en_GB/document_library/Summary_of_opinion/human/000741/WC500144827.pdf) state that ‘Vectibix (Panitumumab) is indicated for the treatment of adult patients with wild-type RAS metastatic colorectal cancer (mCRC)’, without specifically stating which codons must be tested. Here, EGFR is linked to metastatic colorectal cancer.