In human colon cancer colo 205 cells, α-mangostin induced cytotoxic effects in a dose and time-dependent manner and induced apoptosis through extrinsic and intrinsic pathways including expression of caspase-3,-8,-9, release of cytocrome c from mitochondria and up-regulation of Bax, Bmf, Bak, Bid and p53 [127]. Here, TP53 is linked to malignant colon neoplasm.