The link between miRNAs and CRC progression has been described previously in mechanistic studies presenting that important proteins involved in key signaling pathways of CRC, such as Wnt/β-catenin, phosphatidylinositol 3-kinase (PI3K), KRAS, tumor protein 53 (p53) that are influenced by miRNA expression [47]. This evidence concerns the gene TP53 and colorectal carcinoma.