Another recent study has demonstrated that 1,25(OH)2D3 up-regulates miR-627 and contributes to the anticancer properties of vitamin D in colon cancer by targeting histone demethylase JMJD1A [146], thereby inhibiting proliferation of colon cancer cells in vitro and in vivo through epigenetic regulation. The gene discussed is KDM3A; the disease is malignant colon neoplasm.