We previously stained 111 paraffin-embedded human colorectal cancer tissues using an anti-FAM83H antibody8, and detected staining for FAM83H in the nucleus in three of the tissue samples tested (Fig. 1a); therefore, we hypothesized that FAM83H and its interacting protein CK1α may be localized in the nucleus in some colorectal cancer cells. The gene discussed is SACK1H; the disease is colorectal cancer.