In our previous study8, we immunohistochemically examined colorectal cancer tissues collected from 111 patients using an anti-FAM83H antibody, and noted that staining for FAM83H was preferentially detected in the nucleus in a small subset of colorectal cancer tissues (Fig. 1a); therefore, we hypothesized that FAM83H is present in the nucleus and may recruit CK1α to the nucleus rather than on keratin filaments. The gene discussed is SACK1H; the disease is colorectal cancer.