To explore whether transcriptional levels of cell‐membrane receptors involved in LDL uptake are affected in the PBL fraction of FH patients, we analysed mRNA ‐expression of LRP1, LRP5, LDLR and HMGCR by real‐time PCR in the three groups of young individuals (control non‐FH‐LLT−, FH‐LLT− and FH‐LLT+), with an average age of 35 years. This evidence concerns the gene LRP1 and familial hyperaldosteronism.