Supporting these finding in animal models, human LRP6 genetic variants that impair Wnt/β‐catenin signalling have been associated with increased risk of carotid atherosclerosis 77 and early coronary artery disease 78 in humans, suggesting protective and anti‐atherogenic effects associated to canonical Wnt/β‐catenin signalling. The gene discussed is LRP6; the disease is coronary artery disorder.