At baseline, expression levels of LRP5 did not differ significantly between macrophages obtained from controls and FH patients (Fig. 1A); however, FH‐MACs showed a significant increase in LRP5 gene transcription when exposed to agLDL (1.63‐fold increase; P < 0.001), an effect that was also found, although with lower intensity level, in control MACs (1.40‐fold increase; P = 0.045). This evidence concerns the gene LRP5 and familial hyperaldosteronism.