LDLR and HMGCR gene expression levels were significantly decreased in PBL from FH patients with respect to the healthy controls, independently of the lipid‐lowering therapy (FH‐LLT−: LDLR, P = 0.043 and HMGCR, P = 0.034; FH‐LLT+: LDLR, P = 0.020 and HMGCR, P = 0.012). This evidence concerns the gene HMGCR and familial hyperaldosteronism.