We performed a step-wise multiple linear regression analysis to determine whether ΔLDL-C was associated with age, gender, IFN-free regimen, clinical condition of liver disease, HCV-RNA, HCV core antigen level, BMI, AST, ALT, γ-GTP, platelet count, AFP, TC, LDL-C, TG, ΔHCV core antigen or ΔHCV-RNA. The gene discussed is IFNA1; the disease is liver disorder.