Treatment of androgen-sensitive human prostate adenocarcinoma cells (LNCaP) with WIN-55,212-2 (WIN), the cannabinoid and CB1 agonist, results in a significant decrease in the expression of Proliferating Cell Nuclear Antigen (PCNA), an essential processivity factor for DNA replication [40]. The gene discussed is PCNA; the disease is prostate adenocarcinoma.