Consistent with the results from the network analysis, genes identified in the meta-analysis were enriched in several pathways including cytokine signaling, lipid metabolism, NOD1/2 signaling, insulin signaling, glucose metabolism, lysosome, nicotinamide metabolism, type 1 diabetes, spliceosome and protein folding (Fig. 5). The gene discussed is INS; the disease is type 1 diabetes mellitus.