Shared genes identified in meta-analysis were enriched in several pathways including cytokine signaling, lipid metabolism, nucleotide-binding oligomerization domain-like receptors 1 and 2 (NOD1/2) signaling, insulin signaling, glucose metabolism, lysosome, nicotinamide metabolism, type 1 diabetes, spliceosome and protein folding (Fig. 5). The gene discussed is INS; the disease is type 1 diabetes mellitus.