Replacing in model 3, Table 3, HDL-C with apoA-I (values were missing in 18 % of the sample) showed tendency to protect against CHD in women (p = 0.062) along with mild attenuation of the RR of obesity (p = 0.053), while apoA-I was not protective in men (p = 0.48), age, SBP and total cholesterol retaining their significant predictive abilities. The gene discussed is APOA1; the disease is obesity due to melanocortin 4 receptor deficiency.