Our result found that the frequency of A allele was a little higher in controls than that in patients (55.0% versus 48.1%), but the A allele of IL-18 −607C/A polymorphism was associated with increased the risk of cerebral infarction (A versus C: OR=0.76, 95% CI=0.69–0.84, P<0.00001). This evidence concerns the gene IL18 and brain infarction.