The frequency of T allele was shown to be higher in cases than that in controls (53.5% versus 43.7%), and our result identified that IL-1α −899C/T polymorphism was associated with cerebral infarction risk under each genetic models (T versus C: OR=1.69, 95% CI=1.33–2.14, P<0.0001; TT versus CC: OR=2.32, 95% CI=1.34–3.99, P=0.002; CT versus CC: OR=1.66, 95% CI=1.44–1.91, P<0.00001; TT + CT versus CC: OR=1.89, 95% CI=1.46–2.44, P<0.00001; TT versus CT + CC: OR=1.76, 95% CI=1.18–2.64, P=0.006) as shown in Figure 2. Here, IL1A is linked to cerebral infarction.