CCN2 and glaucoma: Esson et al. also performed a microarray analysis of blebs after glaucoma filtration surgery in Sprague Dawley rats and found a significant treatment effect in 923 genes.7 Their results confirmed the expression patterns of known mediators of the bleb scarring process, including transforming growth factor-β, connective tissue growth factor, matrix metalloproteinases, and structural proteins like collagens.