When serum was available, IgE antibodies to gelatin were detected in 25/27 (93 %) of those with anaphylaxis, 27/48 (56 %) of those with urticaria, 8/90 (9 %) of those with a generalized eruption, 0/41 with a local reaction only, and 0/29 control subjects [55] (C). Here, IGHE is linked to anaphylaxis.