PPARGC1A and amyotrophic lateral sclerosis: Overexpression of PGC-1α in neurons of SOD1G93A ALS mice improved motor function and survival (Zhao et al., 2011), while overexpressing PGC-1α in fast-twitch muscles of SOD1G37R (glycine to arginine mutation at position 37) ALS mice improved skeletal muscle function and mitochondrial biogenesis, but did not preserve neurodegeneration or extend survival (Da Cruz et al., 2012).