CASR and colonic neoplasm: Extracellular Ca2+ and 1,25(OH)2D upregulate CASR transcription and cyclin-dependent kinase inhibitor expression in the colon and Ca2+ and 1,25(OH)2D may exert their chemopreventative actions with respect to colon cancer, in part, through the CaSR (Chakrabarty et al., 2005).