The obesity associated cytokines like TNF-α and IL-1β increase adipocyte CaSR expression (Cifuentes et al., 2010) by releasing NFκB to translocate to the nucleus and activate the CASR gene at κB response elements in its promoters (Canaff and Hendy, 2005). Here, CASR is linked to obesity due to melanocortin 4 receptor deficiency.