FUS and amyotrophic lateral sclerosis: Similarly, discoveries of mutations in RNA-processing proteins such as TDP-43 (TARDBP) and fused in sarcoma (FUS) were both identified as a cause of FALS and FTD, and subsequently used to generate further models of ALS (Gitcho et al., 2008; Kabashi et al., 2008; Sreedharan et al., 2008; Kwiatkowski et al., 2009; Vance et al., 2009).