SOD1 and amyotrophic lateral sclerosis: While aggregation of misfolded proteins such as SOD1 and NF in ALS has been suggested to cause axonal transport dysfunction, the sequestration of toxic, misfolded protein or hyper phosphorylated proteins into subcellular compartments may in turn be neuroprotective (as previously reviewed in Patzke and Tsai, 2002; Takalo et al., 2013).