Of note the MT stabilizer, Tau (Drubin and Kirschner, 1986), is involved in the pathophysiology of AD (reviewed in Hanger et al., 2014); Mcmurray (2000); Stancu et al. (2014) as well as in other neurodegenerative diseases (collectively tauopathies) such as supranuclear palsy, corticobasal degeneration and Picks disease (reviewed in Cairns et al., 2004). This evidence concerns the gene MAPT and Alzheimer disease.