In addition, the circulating levels of anti-Fn-IgG in patients with CRC group (0.362 ± 0.194) were significantly higher than those of two control groups (0.262 ± 0.152; 0.270 ± 0.162), but there was no significant difference in stage I-II and control group (Fig. 2B). The gene discussed is FN1; the disease is colorectal carcinoma.