Factors that are directly regulated by HIF and are involved in the pathogenesis of acute and chronic kidney diseases include heme oxygenase-1 (HO-1), vascular endothelial growth factor (VEGF), plasminogen activator inhibitor-1 (PAI-1), tissue inhibitor of metalloproteinase-1 (TIMP-1), connective tissue growth factor (CTGF), erythropoietin, Wilms’ tumor suppressor (WT-1), and others [8]. The gene discussed is TIMP1; the disease is chronic kidney disease.