ADCY3 and obesity due to melanocortin 4 receptor deficiency: Consistent with our findings, Pitman et al. recently revealed that mice carrying a gain-of-function mutation in Adcy3 (Adcy3Jll/+) were protected from diet-induced obesity due to increased oxygen consumption and physical activity without a change in food intake compared to their WT littermates during the 7 days of whole-body metabolic measurements15.