In the subgroup of patients with paroxysmal AF (N = 88), after multivariable analyses, Gal-3 level was the only independent predictor of recurrences (HR = 1.13 [1.04–1.22] per unit increase, p = 0.004), LAD not being significant (HR = 1.05 [0.98–1.14] per unit increase, p = 0.15). This evidence concerns the gene LGALS3 and Paroxysmal atrial fibrillation.