This study showed that: (1) Gal-3 levels and LAD are strong independent predictors of recurrence after AF ablation, whatever the type of AF (paroxysmal or persistent); (2) when combined, Gal-3 levels and LAD identify patients at low, intermediate and high risk of arrhythmia recurrence at 1 year, whatever the type of AF. This evidence concerns the gene LGALS3 and cardiac arrhythmia.