PNPLA2 and obesity due to melanocortin 4 receptor deficiency: Interestingly, the levels of transcription factors and enzymes involved in lipogenesis were also enhanced in the VC of B-Atgl-KO male mice, suggesting an increase in futile GL/NEFA cycling [11] coupled with enhanced NEFA β-oxidation, which can also contribute to the increased EE and protection against diet-induced obesity.