Similar to WGBS, promoters of Sgk3, Nfam1, Pstpip2, and Plscr1 were found to be hypermethylated in normal B-1a cells, normal CD8 T cells, and Dnmt3aΔ/ΔPTCL, but were hypomethylated in three independent Dnmt3aΔ/Δ CLL samples (Fig. 5a). Here, NFAM1 is linked to B-cell chronic lymphocytic leukemia.