Lastly, recent studies using Mx1-Cre transgene to conditionally delete Dnmt3a in HSPCs followed by transplantation into lethally irradiated recipients showed that the vast majority of mice (69%) develop myeloid disorders such as MDS and AML with rare occurrences of CD4+ CD8+ double positive T-ALL or B-ALL18, 19. This evidence concerns the gene DNMT3A and acute lymphoblastic leukemia.