Although no comparable large scale profiling of the methylation landscape has been performed on TCL to date, our functional studies utilizing EμSRα-tTA;Teto-Cre;Dnmt3afl/fl;Rosa26 LOXPEGFP/EGFP mice demonstrated that Dnmt3a likely play a role in pathogenesis of PTCL. The gene discussed is DNMT3A; the disease is mature T-cell and NK-cell non-Hodgkin lymphoma.