In PTCL one of the candidate oncogenes is STAT1 (Signal transducer and activator of transcription 1), whose inappropriate activation has been observed in a variety of malignant cells from breast cancer, head and neck squamous carcinoma, melanoma, lymphoma and leukemia, suggesting that STAT1 may under specific conditions contribute to malignant transformation23. This evidence concerns the gene STAT1 and melanoma.