Interestingly, we have not observed the development of myeloid malignancies in EμSRα-tTA;Teto-Cre;Dnmt3afl/fl;Rosa26LOXPEGFP/EGFP model, despite the fact that Dnmt3a – like in Mx1 - Cre;Dnmt3afl/fl model – is conditionally inactivated in HSPCs and all hematopoietic lineages. The gene discussed is MX1; the disease is myeloid neoplasm.