CD8A and B-cell chronic lymphocytic leukemia: Similar to WGBS, promoters of Sgk3, Nfam1, Pstpip2, and Plscr1 were found to be hypermethylated in normal B-1a cells, normal CD8 T cells, and Dnmt3aΔ/ΔPTCL, but were hypomethylated in three independent Dnmt3aΔ/Δ CLL samples (Fig. 5a).