CRHR2 and autoimmune disease: In addition to the genome-wide significant association at 6q25.3 locus, we also observed suggestive evidence for association at eight additional loci (5 × 10−8<P value<5 × 10−5; Supplementary Fig. 6 and Supplementary Table 5), among which, KIF21B, CACNA1S, CRHR2, BDKRB2 and TPM4 have been reported to be involved in pathogenesis of autoimmune disease, inflammatory disease or response to bacterial infection16, 17, 18, 19, 20, 21, 22.