Single-nucleotide polymorphisms (SNPs) at several loci have been reported to be associated with OM, such as those at 10q26.3, 19q13.43, 17q12, 10q22.3, 2q31.1 for association with chronic and recurrent OM10, 11, 12, 13, 2p23.1 (genes CAPN14, GALNT14) and 20q11.21 (BPIFA gene) for association with OM in general14. This evidence concerns the gene CAPN14 and ocular melanoma.