Dysfunction of the astrocyte K+ channel Kir4.1, encoded by the KCNJ10 gene (OMIM602208), is a common substrate to a number of neuronal phenotypes in several syndromic or non-syndromic neurodevelopmental disorders presenting with broad clinical manifestations and encompassing movement disorders, intellectual disability, autism spectrum disorders (ASD), and seizures1. This evidence concerns the gene KCNJ10 and autism spectrum disorder.