In the CAMELIA trial mortality amongst the 155 TB-IRIS cases was higher than in our study (23 deaths among the 155 patients (14.8 %) with 6 deaths attributed to TB-IRIS), likely a consequence of the advanced immunosuppression at ART initiation in the CAMELIA participants (median CD4 = 27 cells/μl) [7]. This evidence concerns the gene CD4 and tuberculosis.