On the other hand, to date we and others have independently reported that circulating ANGPTL2 levels increase in various pathological conditions other than obesity accompanied by adipose tissue inflammation, such as atherosclerotic vascular disease and type 2 diabetes and that these levels are associated with disease severity17, 20, 39, 40, 41. This evidence concerns the gene ANGPTL2 and obesity due to melanocortin 4 receptor deficiency.