Immunohistochemistry with an anti-ANGPTL2 antibody revealed abundant ANGPTL2 protein in αMHC-positive cardiomyocytes and CD31-positive capillary vessel endothelial cells but not in periostin-positive cardiac fibroblasts in tissues from all three CHF patients (Fig. 8e for representative results from CHF case 3). This evidence concerns the gene POSTN and congestive heart failure.