Both Ang II and Iso reportedly promote nuclear translocation of NFAT26, 27, a key transcription factor underlying development of pathological cardiac remodelling28, and we previously reported that the presence of a complex of NFAT, ATF2 and c-jun is associated with increased Angptl2 transcription in lung and breast tumour cells22. Here, ANGPTL2 is linked to breast neoplasm.