In some contexts, ANGPTL2 overexpression promotes irreversible pathological tissue remodelling and development or progression of obesity-associated metabolic diseases, type 2 diabetes, atherosclerotic vascular diseases and some cancers16, 17, 18, 19, 20, 21, 22, 23. This evidence concerns the gene ANGPTL2 and obesity due to melanocortin 4 receptor deficiency.