HAVCR1 and acute kidney injury: In addition to the highly upregulated Havcr1 and Lcn2 late after AKI, increased expression of genes encoding amiloride binding protein-1, vascular cell adhesion molecule, and endothelin has been shown in the repaired kidneys, which is believed to explain the salt-sensitive hypertension after AKI and contribute to the CKD progression31, 35, 50, 51.