When combining IgG1 and IgG3 to all PvRBPs in a multivariate model, however, only IgG1 to PvRBP1a (IRRH 0.56, 95%CI 0.39–0.80, P = 0.001) and PvRBP2b (IRRM 0.64, 0.46–0.90, P = 0.011; IRRH 0.69, 95%CI 0.48–0.97, P = 0.035) remained associated with reduced risk of vivax-malaria. Here, IGHG3 is linked to malaria.