IGHG3 and malaria: For the young PNG children included in this study, a reduction in risk of vivax-malaria was observed with IgG3 to PvRBP1a, PvRBP2a and PvRBP2-P2 but, ultimately, it was IgG1 to PvRBP1a and PvRBP2b that showed the strongest associations with protection.