IGHG3 and malaria: After adjusting for confounders, both IgG1 and IgG3 to PvRBP1a (IgG1 IRR 0.48, P < 0.001; IgG3 IRR 0.51–0.67, P < 0.001–0.011) and PvRBP2a (IgG1 IRR 0.66, P = 0.010; IgG3 IRR 0.51, P < 0.001–0.011), and only IgG3 to PvRBP2-P2 (IRR 0.60, P = 0.002) were associated with reduced risk of vivax-malaria.