These efforts, along with other modes of HuR inhibition (i.e., targeted siRNA delivery [53]), being evaluated in pre-clinical models for: 1) targeting specificity, 2) toxicity profiles, and 3) therapeutic effects against malignant phenotypes, will further support the notion that HuR is a valuable target in CRC and that pharmacological HuR inhibitors such as MS-444 warrant further investigation. This evidence concerns the gene ELAVL1 and colorectal carcinoma.