Because α7nAChR is a demonstrable mediator of the cholinergic anti-inflammatory pathway expressed in cytokine-producing splenic macrophages25, 34 but also integrates the sympathetic and parasympathetic systems in presynaptic neurons of the splenic nerve26, we sought to understand where α7nAChR acts in hypertension. The gene discussed is CHRNA7; the disease is hypertensive disorder.