Extending previous results in rats in which modulation of CB1R or genetic removal of FAAH negatively impacted social interactions,79, 88 researchers examined the influence of AEA on social behaviors via FAAH modulation.13 A social approach task and elevated plus maze were used to assess the effects of increased AEA (via FAAH inhibition) on social motivation in BTBR mice (an idiopathic ASD model with known deficits in social approach, reciprocal social interaction, and juvenile play) and Fragile X Syndrome mice (a syndromic ASD model with persistent social approach deficits). This evidence concerns the gene FAAH and fragile X syndrome.