A number of ligands for RAGE have been identified, including advanced glycation end products (AGEs), which are well known for their role in diabetes and athlerosclerosis, inflammatory mediators such as members of the S100/calgranulin family, high mobility group box 1 protein (HMGB-1), the Mac-1 integrin, and amyloid beta (Aβ), found in the senile plaques of AD brains [13–15]. Here, AGER is linked to Alzheimer disease.